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吴武田教授自然子刊解析神经研究新发现

来源: 作者: 2018-09-26 11:21:18

吴武田教授《自然》子刊解析神经研究新发现

生物通报道:来自美生物制药公司Biogen Idec Inc,中国香港大学解剖学系,脑与认知科学国家重点实验室(State Key Laboratory of Brain and Cognitive Sciences)等研究人员发现了一种治疗中枢神经系统CNS脱髓鞘疾病(demyelinating diseases)的新方法,这种方法的机制即LINGO-1或其途径在体内体外少突胶质细胞(Oligodendrocyte)分化和髓鞘(myelination)中的负调控作用。这一研究成果公布在《Nature Medicine》杂志上。

领导这一研究的是香港大学医学院解剖学系副教授,中山大学客座教授的吴武田教授,其一直致力于神经损伤和再生机制方面的基础研究。

脱髓鞘疾病(demyelinating diseases),譬如多发性硬化症(multiple sclerosis,MS,一种自体免疫性疾病(autoimmune disease),即患者体内的免疫系统无法分辨何者是自己的细胞,何者为外来侵犯物,造成免疫系统攻击自身的组织)的一个重要特征就是神经细胞周围髓鞘(myelin sheath)丢失,这主要是因为中枢神经系统(central nervous system,CNS)中发生了炎症反应和胶质增生(gliosis)。

因此目前的治疗主要是靶向抗炎机制,达到阻碍或延缓疾病扩散的目的,而针对轴突髓鞘质(myelin)的一种方法则提供了抑制以及可能逆转疾病扩散的新治疗方法,之前的研究发现含亮氨酸重复序列和免疫球蛋白结构域的Nogo受体作用蛋白(LRR and Ig domain—containing,Nogo Receptor—interacting protein,LINGO-1)是一种体内体外少突胶质细胞(Oligodendrocyte)分化和髓鞘(myelination)的负调控因子。

在这篇文章中,研究人员利用Lingo1基因敲除或者抗LINGO-1功能的抗体造成LINGO-1功能缺失,结果发现这种缺陷型中实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis)功能复原,这通过生物性轴突完整性增加——弥散张量磁共振成像(magnetic resonance diffusion tensor imaging)和髓鞘新形成——电子显微(electron microscopy)获得确认。从而研究人员提出针对LINGO-1或其途径的对抗治疗是一种治疗中枢神经系统CNS脱髓鞘疾病的新方法。(生物通:张迪)

原文摘要:Nature Medicine 13, 1228 - 1233 (2007) Published online: 30 September 2007 | doi:10.1038/nm1664LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis 『Abstract』

吴武田 教授 姓  名:吴武田性  别:男职  称:教授学  历:博士研究生何种导师: 博士生导师学科专业:人体解剖与组织胚胎学; 神经生物学研究方向:神经损伤和再生机制的基础研究行政职务: E-mail: wtwu@ :(852)(O) 一般简介:吴武田, 神经科学博士,博士生导师。

年,美国Graduate School of Old Domonion University and Eastern Virginia Medical School,神经科学博士;年,美国Eastern Virginia Medical School神经科学系,助理教授;年香港大学解剖系,助理教授;1997年至今,香港大学医学院解剖学系,副教授。中山大学客座教授。

Journal of Histochem Cyrochem、Brain research、Experimental Neurology和Journal of Comparative Neurology的审稿专家;美国PVA脊髓研究基金委员会、美国Paralysis研究基金会评审专家。

近20年来,吴武田博士一直致力于“神经损伤和再生机制的基础研究”,先后承担美国科研基金5项(其中有NIH基金),香港科研基金8项。发表论文80余篇,被引频次1000余次,直接指导博士生11名,博士后13名。吴武田博士是脊髓损伤研究领域的国际知名学者,曾四次应邀在国际神经科学会议上作:“神经移植、NOS在神经损伤和再生中的作用”的专题报告。并应邀参编着名神经科学丛书:“Handbook of Chemical Neuroanatomy”。还作为分课题负责人承担年 国家科技部重大项目基金(973项目)---“神经损伤的修复和重建的应用研究”。2003年以来主要科研论文如下:1. Chan, Y.M., Yick, L.W., Yip, H.K., So, K-F, Oppenheim, R.W. and Wu, W.*: Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats. Experimental Neurology, 181:, 2003. (Wu, W: corresponding author). 2. Wu, W.*, Li, L., Yick, L.W., Chai, H., Xie,Y.Y., Yang, Y., Prevette, D.M. and Oppenheim, R.W.: GDNF and BDNF alter the expression of NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion. J. Neurotrauma, 20:, 2003. (Wu, W: corresponding author). 3. Xie, Y.Y., Yao, Z.B., Chai, H., Wong, W.M. and Wu, W.*: Re-expression and regulation of low-ffinity nerve growth factor receptor (p75) in spinal motor neurons of aged rats following axonal injury. Developmental Neuroscience, 25:, 2003. (Wu, W: corresponding author). 4. Xie, Y.Y., Yao, Z.B., Chai, H., Wong, W.M. and Wu, W.*: Potential roles of Alzheimer precursor protein A4 and b-Amyloid in the survival and function of aged spinal motor neurons following axonal injuries. J. Neuroscience Research, 73:, 2003. (Wu, W: corresponding author). 5. Yaun, Q, Wu, W.*, So, K-F: Inflammatory response of spinal motoneurons to axonal injury in newborn rats. Developmental Neuroscience, 25:, 2003. (Wu, W: corresponding author). 6. Yick, L.W., Cheung, P.T., So, K-F and Wu, W.*: Axonal regeneration of Clarke’s neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC. Experimental Neurology, 182:, 2003. (Wu, W: corresponding author). 7. Gu, H.Y., Chai, H., Zhang, J.Y., Yao, Z.B., Zhou, L.H., Bruce, I. and Wu, W.*: Survival, regeneration and functional recovery of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion. Europ. J. Neurosci. 19:, 2004. (Wu, W., corresponding author). 8. Wu, W.*, Chai, H., Zhang, J.Y., Gu, H.Y., Xie, Y.Y. and Zhou, L.H.: Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats. J. of Neurotrauma, 21(8): , 2004. (Wu, W.., corresponding author). 9. Yick,L.W., So, K-F, Cheung, P.T. and Wu, W.*: Lithium chloride reinforces the regeneration-promoting effect of chondroitinase ABC on rubrospinal neurons after spinal cord injury. J. of Neirotrauma, 21(7):, 2004. (Impact:2.866; Citation:2). 50% 10. Gu, H.Y., Chai, H., Zhang, J.Y., Yao, Z.B., Zhou, L.H., Wong, W.M., Bruce, I. and Wu, W.*: Survival, regeneration and functional recovery of motoneurons after delayed reimplantation of ventral root in adult rat. Exp. Neurol. 192:, 2005. (Wu, W., corresponding author). 11. Zeng, Y.S., Ding, Y., Wu, L.Z., Guo, J.S., Li, H.B. and Wu, W.*: Co-transplantation of Schwann cells promotes the survival and differentiation of neural stem cells transplanted into the injured spinal cord. Dev. Neurosci. 27:, 2005. (Wu, W., corresponding author). 12. Chu, T.H. and Wu, W.*: Nitric oxide synthase inhibitor attenuates number of regenerating spinal motoneurons in adult rats. Neuroreport. 17(10):. 2006. (Wu, W., corresponding author).13. Yang, Y., Xie, Y.Y., Chai, H., Fan, F., Liu, S.H., Liu, H., Bruce, I., and Wu, W.*: Microarray Analysis of Gene Expression Patterns in Adult Spinal Motoneurons after Different types of Axonal Injuries. Brain Res. 1075:, 2006. (Wu, W., corresponding author). 14. Yuan, Q.J., Scott, D.E., So, K.F. and Wu, W.*: Developmental changes of nitric oxide synthase expression in the rat hypothalamo-neurohypophyseal system. Anat. Record. 288A:, 2006. (Wu, W., corresponding author). 15. Yuan, Q.J., Hu, B, So, K.F. and Wu, W.*: Age-related reexpression of p75 in axotomized motoneurons. NeuroReport, 17:, 2006. (Wu, W., corresponding author).16. Yuan, Q., Scott, D.E., So, K.F. and Wu, W.*: The response of magnocellular neurons of the hypothalamo-neurohyphyseal system to hypophysectomy, nitric oxide synthase expression as well as survival and regeneration in developing vs. adult rats. Brain Res. 1113(1):. 2006. (Wu, W., corresponding author).17. Zhou, L.H. and Wu, W.*: Antisense oligos to neuronal nitric oxide synthase aggravate motoneuron death induced by spinal root avulsion in adult rat. Exp. Neurol.197:. 2006. (Wu, W., corresponding author). 18. Zhou, L.H. and Wu, W.*: Survival of injured spinal motoneurons in adult rat upon treatment with glial cell line-derived neurotrophic factor at 2 weeks but not at 4 weeks after root avulsion. J Neurotrauma. 23(6):. 2006. (Wu, W., corresponding author).19. Guo, J.S., Zeng, Y.S., Liang, Y.X., Wang, L., Su, H.X., Wu, W.*: Cyclosporine affects the proliferation and differentiation of neural stem cells in culture. Neuroreport, 18(9):. 2007. (Wu, W., corresponding author). 20. Su, H.

吴武田教授自然子刊解析神经研究新发现

, Chu, T.H. and Wu, W.*: Lithium enhances proliferation and neuronal differentiation of neural progenitor cells in vitro and after transplantation into the adult rat spinal cord. Exp Neurol. 206(2):. 2007. (Wu, W., corresponding author).21. Yuan, Q., Scott, D.E., So, K.F. and Wu, W.*: Differential Activation of c-fos Immunoreactivity After Hypophysectomy in Developing and Adult Rats. Anat Rec (Hoboken). 290(9):. 2007. (Wu, W., corresponding author).22. Yuan, Q., Scott, D.E., So, K.F. and Wu, W.*. A subpopulation of reactive astrocytes at affected neuronal perikarya after hypophysectomy in adult rats. Brain Res. 1159:. 2007. (Wu, W., corresponding author).23. Zeng, Y.S., Nie, J.H., Zhang, W., Chen, S.J. and Wu, W.*: Morphine acts via -opioid receptors to enhance spinal regeneration and synaptic reconstruction of primary afferent fibers injured by sciatic nerve crush. Brain Res, 1113:. 2007. (Wu, W., corresponding author).




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